Bacterial Glycolipids

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Bacterial glycolipids.

INTRODUCTION............................................................. 365 ISOLATION AND PURIFICATION................................... 365 CHEMISTRY OF GLYCOLIPIDS................................... 366 Glycosyl Diglycerides................................... 366 Acylated Sugar Derivatives................................................... 369 BIOSYNTHESIS.....................................

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Novel interactions of glycosaminoglycans and bacterial glycolipids mediate binding of enterococci to human cells.

Enterococcus faecalis is among the most important nosocomial pathogens. The intestinal mucosa is considered to be the main site used by these bacteria for entrance and dissemination. A better understanding of the mechanisms involved in colonization and invasion of enterococci may help to devise methods to prevent infections in hospitalized patients. Glycosaminoglycans, which are present on the ...

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Bacterial glycolipids and analogs as antigens for CD1d-restricted NKT cells.

The CD1 family of proteins binds self and foreign glycolipids for presentation to CD1-restricted T cells. To identify previously uncharacterized active CD1 ligands, especially those of microbial origin, numerous glycolipids were synthesized and tested for their ability to stimulate mouse and human natural killer T (NKT) cells. They included analogs of the well known NKT cell agonist alpha-galac...

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Enterococcus faecalis Glycolipids Modulate Lipoprotein-Content of the Bacterial Cell Membrane and Host Immune Response

In this study, we investigated the impact of the cell membrane composition of E. faecalis on its recognition by the host immune system. To this end, we employed an E. faecalis deletion mutant (ΔbgsA) that does not synthesize the major cell membrane glycolipid diglycosyl-diacylglycerol (DGlcDAG). Proteomic analysis revealed that 13 of a total of 21 upregulated surface-associated proteins of E. f...

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Glycolipids anchor laminin

Boundary proteomics pecialized regions of chromatin flank the edges of transcriptionally silent DNA, separating it from euchromatin. For example, such boundary elements insulate the silent mating type loci ( HMR and HML ) in yeast. The molecular nature of these boundaries has remained obscure. Now, Tackett et al. (page 35) have identified protein complexes that are important for maintaining suc...

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ژورنال

عنوان ژورنال: Bacteriological Reviews

سال: 1970

ISSN: 0005-3678

DOI: 10.1128/mmbr.34.4.365-377.1970